Protective effect by UCB JO28 against histamine and methacholine induced bronchial hyperreactivity.

Abstract

UCB JO28 [( 2-[2-[4-(diphenylmethylene)-1-piperidinyl] ethoxy] ethoxy] acetic acid, hydrochloride) is derived from diphenylmethylene piperidine. Animal experiments have shown that it has spasmolytic properties for smooth muscle, particularly in the bronchi, as well as anti-Hl, anticholinergic and anti-serotonin activities. The degree of protection by JO28 against histamine and methacholine-induced bronchospasm has been investigated in 20 asthmatic patients with serious airways hyper-reactivity. Protection against histamine-induced bronchospasm was almost complete in 11 out of 12 patients, whereas protection against methacholine-induced bronchospasm, although clearly present in seven of eight patients, was less marked.

• Authors: F P Maesen, J J Smeets, E Baltes, J P Rihoux
• Journal: European journal of clinical pharmacology (Eur J Clin Pharmacol) Vol. 28 Issue 5 Pg. 517-21 ( 1985) ISSN: 0031-6970 [Print] Germany
• PMID: 3899673 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• Methacholine Compounds
• Piperidines
• Methacholine Chloride
• Histamine
• UCB JO28

Topics

• Adolescent
• Adult
• Asthma (drug therapy)
• Bronchial Spasm (blood, chemically induced, drug therapy)
• Clinical Trials as Topic
• Female
• Histamine (adverse effects)
• Humans
• Male
• Methacholine Chloride
• Methacholine Compounds (adverse effects)
• Middle Aged
• Piperidines (blood, therapeutic use)
• Prospective Studies