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Efficacy of BMY-28142 in experimental bacteremia and meningitis caused by Escherichia coli and group B streptococci.

Abstract
We evaluated the activity of BMY-28142 against a K1 E. coli strain and a type III group B streptococcal strain in vitro and in vivo and compared the results with those of cefotaxime and penicillin G, respectively. In vitro, the MICs and MBCs of BMY-28142 were close to those of cefotaxime (less than or equal to 2-fold difference) for E. coli and fourfold less than those of penicillin G for group B streptococci. In vivo studies with an experimental bacteremia and meningitis model in newborn rats revealed that the mean penetration of BMY-28142 into the cerebrospinal fluid was 15% that of concomitant levels in serum and that significantly greater bactericidal titers were achieved in blood and cerebrospinal fluid for both test organisms with BMY-28142 than with cefotaxime and penicillin G. However, the overall efficacy of BMY-28142 was similar to that of cefotaxime for the E. coli infection and that of penicillin G for the group B streptococcal infection. This was shown by similar rates of bacterial clearance from blood and cerebrospinal fluid and similar mortality rates. These findings indicate that the activity of BMY-28142 is bactericidal in vitro and in vivo against E. coli and group B streptococci, suggesting that this agent may be a suitable alternative for the therapy of E. coli and group B streptococcal bacteremia and meningitis.
AuthorsK S Kim, A S Bayer
JournalAntimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 28 Issue 1 Pg. 51-4 (Jul 1985) ISSN: 0066-4804 [Print] United States
PMID3899006 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Cephalosporins
  • Cefepime
  • Cefotaxime
  • Penicillin G
Topics
  • Animals
  • Cefepime
  • Cefotaxime (therapeutic use)
  • Cephalosporins (therapeutic use)
  • Escherichia coli (drug effects)
  • Female
  • Meningitis (drug therapy, microbiology)
  • Microbial Sensitivity Tests
  • Penicillin G (therapeutic use)
  • Pregnancy
  • Rats
  • Rats, Inbred Strains
  • Sepsis (drug therapy, microbiology)
  • Streptococcal Infections (drug therapy, microbiology)
  • Streptococcus agalactiae (drug effects)

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