[Clinical trial of drugs for treating urological infections--pipemidic acid].

Abstract

A method was elaborated for clinical trial of pharmaceuticals for the treatment of infections of kidneys and urinary ducts. The main requirements are as follows: definitive diagnostic criteria for urological infection, monotherapy, systematic control for the drug intake, precisely formulated indices for assessment of the effect, strict follow-up of adverse and toxic effects. The effect was assessed according to a three-stage scale: very good, good and poor, consideration given not only to the clinical and laboratory indices but to adverse effects as well. Pipemidic acid was studied according to that model--the acid being a new chemotherapeutic, similar to nalidixic acid according to chemical composition and action. Out of all 29 patients treated, 19 were with very good effect, with good--6, and with poor--4. The adverse effects were negligible--one patient had light urticarial rash and pruritus.

• Authors: N Belovezhdov, Ch Talakova, I Angelova, I Chakŭrski, A Koĭchev
• Journal: Vutreshni bolesti (Vutr Boles) Vol. 24 Issue 2 Pg. 61-5 ( 1985) ISSN: 0506-2772 [Print] Bulgaria
• Vernacular Title: Klinichno izpitvane na lekarstveni sredstva za lechenie na uroinfektsii--pipemidinova kiselina.
• PMID: 3898589 (Publication Type: Clinical Trial, English Abstract, Journal Article)

Chemical References

• Nicotinic Acids
• Pipemidic Acid

Topics

• Adult
• Aged
• Bacteria (drug effects)
• Bacterial Infections (drug therapy, microbiology)
• Clinical Trials as Topic (methods)
• Female
• Humans
• Male
• Microbial Sensitivity Tests
• Middle Aged
• Nicotinic Acids (therapeutic use)
• Pipemidic Acid (adverse effects, pharmacology, therapeutic use)
• Urinary Tract Infections (drug therapy, microbiology)