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Efficacy of single- versus multiple-dose clotrimazole therapy in the management of vulvovaginal candidiasis.

Abstract
Single-dose treatment of vulvovaginal candidiasis with a 500 mg clotrimazole vaginal tablet was compared to 3-day treatment with two 100 mg vaginal tablets administered daily in 115 patients enrolled in a double-blind trial, 101 of whom were evaluated for efficacy. Patients with clinically and mycologically active disease were treated (visit 1) and examined at 5 to 10 days (visit 2) and again at least 27 days (visit 3) post treatment. At visit 2, mycologic tests and clinical examinations were negative in 37 of 48 patients receiving single-dose treatment (77%) and in 47 of 53 patients receiving 3-day treatment (89%). Corresponding results for visit 3 were 65% and 74%, respectively. There were no significant differences in treatment response between groups, and only three patients reported adverse reactions. These data show that single-dose treatment with clotrimazole, 500 mg, is as safe and effective as the more complex 3-day regimen.
AuthorsT Lebherz, E Guess, N Wolfson
JournalAmerican journal of obstetrics and gynecology (Am J Obstet Gynecol) Vol. 152 Issue 7 Pt 2 Pg. 965-8 (Aug 01 1985) ISSN: 0002-9378 [Print] United States
PMID3895962 (Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article)
Chemical References
  • Imidazoles
  • Tablets
  • Clotrimazole
Topics
  • Adult
  • Aged
  • Candidiasis, Vulvovaginal (drug therapy)
  • Clinical Trials as Topic
  • Clotrimazole (administration & dosage, therapeutic use)
  • Double-Blind Method
  • Drug Administration Schedule
  • Female
  • Humans
  • Imidazoles (administration & dosage)
  • Middle Aged
  • Pregnancy
  • Tablets
  • Time Factors

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