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Captopril-induced changes on active and inactive renin in a patient with factor XII congenital deficiency.

Abstract
A linkage between prorenin, renin, and intrinsic coagulation systems has been suggested recently. We studied the behavior of renin, prorenin, and kallikrein in a patient affected by congenital factor XII deficiency. Captopril test, upright posture, and furosemide administration provoked in our patients changes of renin and prorenin similar to those found in normal and hypertensive subjects. Unchanged kallikrein levels confirmed that no interaction between prorenin activation and factor XII-kallikrein system appears to be present.
AuthorsG M Patrassi, F Mantero, F Fallo, A Girolami, F H Derkx
JournalResearch in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie (Res Exp Med (Berl)) Vol. 185 Issue 3 Pg. 217-20 ( 1985) ISSN: 0300-9130 [Print] Germany
PMID3895336 (Publication Type: Journal Article)
Chemical References
  • Enzyme Precursors
  • Furosemide
  • Proline
  • Captopril
  • Kallikreins
  • Renin
Topics
  • Adult
  • Captopril
  • Enzyme Activation
  • Enzyme Precursors (blood)
  • Factor XII Deficiency (blood)
  • Female
  • Furosemide
  • Humans
  • Kallikreins (blood)
  • Posture
  • Proline (analogs & derivatives)
  • Renin (blood)

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