Presence of an estrogen-regulated protein in endometrial cancer.

The presence of an estrogen-regulated protein of Mr 24,000 (24K) was studied in 43 patients diagnosed as having endometrial adenocarcinoma. using an anti-24K monoclonal antibody, a modified immunoperoxidase system (avidinbiotin complex) was used to detect the presence of 24K in formalin-fixed, paraffin-embedded tissue samples. The positivity for 24K was correlated with low tumor histologic grade, few mitotic figures, few nucleoli, and a low degree of nuclear pleomorphism. These data suggest that 24K may be a potential marker of tumor differentiation.
AuthorsG W Sledge Jr, I Ramzy, L G Dressler, F A Dorr, D J Adams, W L McGuire
JournalObstetrics and gynecology (Obstet Gynecol) Vol. 66 Issue 3 Pg. 423-7 (Sep 1985) ISSN: 0029-7844 [Print] UNITED STATES
PMID3895080 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Antibodies, Monoclonal
  • Receptors, Estrogen
  • Adenocarcinoma (analysis, pathology)
  • Adult
  • Aged
  • Antibodies, Monoclonal
  • Carcinoma, Squamous Cell (analysis, pathology)
  • Female
  • Histocytochemistry
  • Humans
  • Immunoenzyme Techniques
  • Middle Aged
  • Mitotic Index
  • Molecular Weight
  • Neoplasm Staging
  • Receptors, Estrogen (analysis)
  • Uterine Neoplasms (analysis, pathology)

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