Presence of an estrogen-regulated protein in endometrial cancer.

Abstract

The presence of an estrogen-regulated protein of Mr 24,000 (24K) was studied in 43 patients diagnosed as having endometrial adenocarcinoma. using an anti-24K monoclonal antibody, a modified immunoperoxidase system (avidinbiotin complex) was used to detect the presence of 24K in formalin-fixed, paraffin-embedded tissue samples. The positivity for 24K was correlated with low tumor histologic grade, few mitotic figures, few nucleoli, and a low degree of nuclear pleomorphism. These data suggest that 24K may be a potential marker of tumor differentiation.

• Authors: G W Sledge Jr, I Ramzy, L G Dressler, F A Dorr, D J Adams, W L McGuire
• Journal: Obstetrics and gynecology (Obstet Gynecol) Vol. 66 Issue 3 Pg. 423-7 (Sep 1985) ISSN: 0029-7844 [Print] United States
• PMID: 3895080 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Antibodies, Monoclonal
• Receptors, Estrogen

Topics

• Adenocarcinoma (analysis, pathology)
• Adult
• Aged
• Antibodies, Monoclonal
• Carcinoma, Squamous Cell (analysis, pathology)
• Female
• Histocytochemistry
• Humans
• Immunoenzyme Techniques
• Middle Aged
• Mitotic Index
• Molecular Weight
• Neoplasm Staging
• Receptors, Estrogen (analysis)
• Uterine Neoplasms (analysis, pathology)