HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Presence of an estrogen-regulated protein in endometrial cancer.

Abstract
The presence of an estrogen-regulated protein of Mr 24,000 (24K) was studied in 43 patients diagnosed as having endometrial adenocarcinoma. using an anti-24K monoclonal antibody, a modified immunoperoxidase system (avidinbiotin complex) was used to detect the presence of 24K in formalin-fixed, paraffin-embedded tissue samples. The positivity for 24K was correlated with low tumor histologic grade, few mitotic figures, few nucleoli, and a low degree of nuclear pleomorphism. These data suggest that 24K may be a potential marker of tumor differentiation.
AuthorsG W Sledge Jr, I Ramzy, L G Dressler, F A Dorr, D J Adams, W L McGuire
JournalObstetrics and gynecology (Obstet Gynecol) Vol. 66 Issue 3 Pg. 423-7 (Sep 1985) ISSN: 0029-7844 [Print] UNITED STATES
PMID3895080 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Antibodies, Monoclonal
  • Receptors, Estrogen
Topics
  • Adenocarcinoma (analysis, pathology)
  • Adult
  • Aged
  • Antibodies, Monoclonal
  • Carcinoma, Squamous Cell (analysis, pathology)
  • Female
  • Histocytochemistry
  • Humans
  • Immunoenzyme Techniques
  • Middle Aged
  • Mitotic Index
  • Molecular Weight
  • Neoplasm Staging
  • Receptors, Estrogen (analysis)
  • Uterine Neoplasms (analysis, pathology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password: