Abstract |
A model of endotoxin-induced shock was developed in anesthetized spontaneously hypertensive rats. E. coli lipopolysaccharide (13 mg/kg i.v.) reduced systolic and diastolic blood pressure by at least 51 mm Hg in 80-90% of rats. Naloxone (1.25-10.0 mg/kg i.v.) partially restored blood pressure of hypotensive rats for 6-15 minutes after injection. Win 44441-3 (0.25-2.0 mg/kg i.v.) raised blood pressure for 3-12 minutes after injection. Ten minute pretreatment with naloxone (10 mg/kg i.v.) or Win 44441-3 (0.5 mg/kg i.v.) did not appreciably reduce the hypotensive effect of E. coli lipopolysaccharide. This model is a rapid and convenient bioassay for evaluating the effects of opioid antagonists in endotoxin shock. In this model naloxone and Win 44441-3 exhibited beneficial effects but a prolonged duration of action of the Win compound over naloxone was not observed.
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Authors | A F DeFelice, J D Norton, H E Lape, W F Michne |
Journal | Neuropeptides
(Neuropeptides)
Vol. 5
Issue 4-6
Pg. 299-302
(Feb 1985)
ISSN: 0143-4179 [Print] Netherlands |
PMID | 3889691
(Publication Type: Journal Article)
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Chemical References |
- Azocines
- Lipopolysaccharides
- Naloxone
- quadazocine
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Topics |
- Animals
- Azocines
(therapeutic use)
- Disease Models, Animal
- Escherichia coli
- Lipopolysaccharides
(pharmacology)
- Male
- Naloxone
(therapeutic use)
- Rats
- Rats, Inbred SHR
- Shock, Septic
(drug therapy)
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