A comparative study of once versus twice daily treatment of superficial dermatophyte and yeast infections with tioconazole (1%) cream.

Abstract

Two open, multicentre studies were performed to evaluate the efficacy of 1% tioconazole cream (Trosyd, Pfizer) as a once daily treatment for patients with common superficial dermatophyte and yeast infections (t. pedis, t. versicolor, t. corporis, t. cruris, candidiasis). In Study I, forty-eight patients were treated once daily and forty-nine were treated twice daily. The clinical response rate at the last treatment visit was 96% and 98%, respectively, in the two treatment groups. In Study II, all 107 patients were treated once daily, and the clinical response rate was 95% at the last treatment visit. The mycological cure rates were 85% and 91% in the Study I groups, and 94% in Study II. At the long-term follow-up evaluation (approximately 4 weeks after treatment) favourable clinical responses were seen in 88% of patients in both the Study I groups, and in 94% of patients in Study II. Long-term mycological cures were seen in 80% of patients in both groups of Study I, and in 94% of patients in Study II. Side-effects of treatment were generally transient, mild and coincident with disease symptoms, and occurred in six patients (6%) in Study I and in four patients (4%) in Study II. The results of both studies have shown no clinically or statistically significant differences in toleration or efficacy between once daily and twice daily treatment regimens with 1% tioconazole cream for the treatment of superficial dermatophyte infections.

• Authors: P Kashin, M C Phyfferoen, D L Gibbs
• Journal: The Journal of international medical research (J Int Med Res) Vol. 13 Issue 2 Pg. 88-95 ( 1985) ISSN: 0300-0605 [Print] England
• PMID: 3888731 (Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antifungal Agents
• Imidazoles
• tioconazole

Topics

• Adolescent
• Adult
• Aged
• Antifungal Agents (therapeutic use)
• Candidiasis (drug therapy)
• Clinical Trials as Topic
• Dermatomycoses (drug therapy)
• Drug Tolerance
• Female
• Humans
• Imidazoles (administration & dosage, adverse effects, therapeutic use)
• Male
• Microscopy
• Middle Aged
• Random Allocation
• Tinea (drug therapy)