| Abstract | Seventy-four children with juvenile chronic arthritis were entered into a 6-month, multicenter, comparative double-blind study of the efficacy of D-penicillamine versus placebo. The results were evaluated in 70 patients, 55 of whom completed 6 months of the study. Improvement was observed in the total number of stiff joints, total number of painful joints, and total severity index measuring joint pain. There was also a significant reduction in the concurrent use of nonsteroidal anti-inflammatory drugs. D-penicillamine was well-tolerated in all but 2 patients. Some children in the placebo group exhibited definite improvement; however, relapses that were observed were mainly in that group. These results confirm the efficacy of D-penicillamine for the treatment of joint involvement in juvenile chronic arthritis. |
| Authors | A M Prieur, C Piussan, P Manigne, P Bordigoni, C Griscelli |
| Journal | Arthritis and rheumatism
(Arthritis Rheum)
Vol. 28
Issue 4
Pg. 376-82
(Apr 1985)
ISSN: 0004-3591 UNITED STATES |
| PMID | 3885958
(Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
|
| Chemical References |
- Anti-Inflammatory Agents
- Placebos
- Penicillamine
- Prednisone
|
| Topics |
- Adolescent
- Anti-Inflammatory Agents
(therapeutic use)
- Arthritis, Juvenile Rheumatoid
(drug therapy)
- Child
- Child, Preschool
- Chronic Disease
- Clinical Trials as Topic
- Double-Blind Method
- Drug Therapy, Combination
- Female
- Humans
- Male
- Penicillamine
(adverse effects, therapeutic use)
- Placebos
- Prednisone
(therapeutic use)
|
