Abstract |
Thirty patients suffering from peripheral vascular disease (stage-II according to Fontaine) were included in a double-blind study aimed at assessing the efficacy of a high-dose glycosaminoglycan (GAG) ( Sulodexide) both in terms of laboratory parameters, such as lipid metabolism and blood coagulation components, and instrumental procedures (strain-gauge plethysmography). Compared with the fifteen control patients (treated with placebo), the fifteen patients treated with Sulodexide showed a significant decrease in blood triglycerides and fibrinogen as well as a significantly increased HDL-cholesterol, and positive instrumental changes: at the end of treatment Peak and Rest Flow values--and consequently also Winsor's index--were significantly increased only in patients treated with Sulodexide.
|
Authors | C Corsi, L Bocci, C Cipriani, A Gazzini, E Marrapodi |
Journal | The Journal of international medical research
(J Int Med Res)
Vol. 13
Issue 1
Pg. 40-7
( 1985)
ISSN: 0300-0605 [Print] England |
PMID | 3884410
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
|
Chemical References |
- Cholesterol, HDL
- Glycosaminoglycans
- Triglycerides
- glucuronyl glucosamine glycan sulfate
- Fibrinogen
|
Topics |
- Aged
- Arteriosclerosis
(drug therapy)
- Cholesterol, HDL
(blood)
- Clinical Trials as Topic
- Double-Blind Method
- Female
- Femoral Artery
- Fibrinogen
(metabolism)
- Glycosaminoglycans
(administration & dosage, therapeutic use)
- Humans
- Intermittent Claudication
(drug therapy)
- Male
- Random Allocation
- Triglycerides
(blood)
- Vascular Diseases
(drug therapy)
|