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Response of a phage modification factor to enhanced production of its target molecule.

Abstract
Escherichia coli cells with plasmids bearing the valS gene were constructed from the Clark-Carbon collection. Their increased valyl-tRNA synthetase (EC 6.1.1.9) activity was not matched by commensurate production of a modifying peptide during T4 infection. Thus, phage vs gene expression is set to modify the normal amount of valyl-tRNA synthetase activity.
AuthorsN J Olson, G L Marchin
JournalJournal of virology (J Virol) Vol. 53 Issue 2 Pg. 702-4 (Feb 1985) ISSN: 0022-538X [Print] United States
PMID3881597 (Publication Type: Journal Article)
Chemical References
  • Viral Proteins
  • Amino Acyl-tRNA Synthetases
  • Valine-tRNA Ligase
Topics
  • Amino Acyl-tRNA Synthetases (metabolism)
  • Escherichia coli (enzymology)
  • Gene Expression Regulation
  • Genes, Viral
  • T-Phages (growth & development, metabolism)
  • Valine-tRNA Ligase (metabolism)
  • Viral Proteins (biosynthesis, genetics)

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