Post-partum thyroiditis and goitrous (Hashimoto's) thyroiditis are associated with HLA-DR4.

Abstract

Using new panels of HLA-DR typing sera, we found an increase in the prevalence of HLA-DR4 in 21 patients with Hashimoto's thyroiditis (57%) and 32 patients with post-partum thyroiditis (53%) compared to controls (21%). Hashimoto's thyroiditis was previously found to be associated with HLA-DR5 and Dw5. We feel that the doubts raised by this study warrant the study of DR antigens in thyroid autoimmune disease using large panels of specific sera.

• Authors: C Thompson, N R Farid
• Journal: Immunology letters (Immunol Lett) Vol. 11 Issue 5-6 Pg. 301-3 ( 1985) ISSN: 0165-2478 [Print] Netherlands
• PMID: 3879239 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• HLA-DR4 Antigen
• Histocompatibility Antigens Class II

Topics

• Diabetes Mellitus, Type 1 (genetics)
• Female
• Genetic Linkage
• Graves Disease (genetics)
• HLA-DR4 Antigen
• Histocompatibility Antigens Class II (analysis)
• Humans
• Major Histocompatibility Complex
• Male
• Pedigree
• Pregnancy
• Puerperal Disorders (immunology)
• Thyroiditis (genetics, immunology)
• Thyroiditis, Autoimmune (genetics, immunology)