Penetration of
aspoxicillin (ASPC), a new semisynthetic
penicillin, to cerebrospinal fluid (CSF) and clinical studies against
bacterial infections were carried out and the following results were obtained. The concentration of ASPC in CSF was below 1 microgram/ml at 1 hour after
intravenous administration of about 50 mg/kg dose to 2 cases of
aseptic meningitis on the acute stage. The concentration of ASPC in CSF was above 10 micrograms/ml at 1 hour after
intravenous administration of about 80 mg/kg dose to 3 cases of purulent
meningitis on the acute stage, and was above 2 micrograms/ml even on the recovering stage. On each stage, its concentration was more than minimum inhibitory concentration of H. influenzae (less than or equal to 0.05 microgram/ml; at inoculum size of 10(6) cells/ml). Clinical efficacy of ASPC was good in all 3 cases of purulent
meningitis, excellent in 3 cases, good in 3 cases and poor in 1 case out of 7 cases of
septicemia, good in 2 cases and poor in 1 case out of 3 cases of
gastroenteritis, respectively. And clinical efficacy of other diseases were excellent or good, that were 2 cases of
tonsillitis, 2 cases of soft tissue
abscess, 1 case of purulent
lymphadenitis and 1 case of
urinary tract infection, respectively. Side effects were mild
eosinophilia in only 2 cases out of 22 cases.