Abstract |
The analgesic, anti-pyretic and anti-inflammatory effects of FI-302, N-(3-piperidinopropyl)-4-methyl-6-trifluoromethyl-furo [3,2-b] indole-2-carboxamide, a newly synthesized tricyclic compound, were investigated in comparison with those of nonsteroidal anti-inflammatory drugs ( NSAIDs). FI-302 showed potent analgesic and antipyretic effects in the various models used. FI-302 showed an inhibitory effect on acute inflammatory response such as carrageenin-induced edema, but did not show any effect on chronic inflammatory response such as cotton pellet granuloma. These effects of FI-302 were about 2 to 7 times more potent than those of non-acidic NSAIDs such as mepirizole and tiaramide. Moreover, FI-302 had little or no ulcerogenic activity. From these results, it is conceivable that the spectrum of FI-302's activities is similar to those of non-acidic NSAIDs such as mepirizole and tiaramide. These results suggest that FI-302 is a new non-ulcerogenic anti-inflammatory compound, and should be suitably applicable for clinical purposes.
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Authors | T Kameyama, F Amanuma, S Okuyama, S Higuchi, H Aihara |
Journal | Journal of pharmacobio-dynamics
(J Pharmacobiodyn)
Vol. 8
Issue 6
Pg. 477-86
(Jun 1985)
ISSN: 0386-846X [Print] Japan |
PMID | 3877158
(Publication Type: Journal Article)
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Chemical References |
- Anti-Inflammatory Agents, Non-Steroidal
- Indoles
- FI 302
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Topics |
- Animals
- Anti-Inflammatory Agents, Non-Steroidal
- Arthritis, Experimental
(prevention & control)
- Capillary Permeability
- Edema
(prevention & control)
- Erythema
(prevention & control)
- Granuloma
(prevention & control)
- Guinea Pigs
- Indoles
(pharmacology)
- Lethal Dose 50
- Male
- Mice
- Rats
- Rats, Inbred Strains
- Stomach Ulcer
(chemically induced)
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