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Pharmacological studies of furo [3,2-b] indole derivatives. I. Analgesic, anti-pyretic and anti-inflammatory effects of FI-302, N-(3-piperidinopropyl)-4-methyl-6-trifluoromethyl-furo [3,2-b]indole-2-carboxamide, in experimental animals.

Abstract
The analgesic, anti-pyretic and anti-inflammatory effects of FI-302, N-(3-piperidinopropyl)-4-methyl-6-trifluoromethyl-furo [3,2-b]indole-2-carboxamide, a newly synthesized tricyclic compound, were investigated in comparison with those of nonsteroidal anti-inflammatory drugs (NSAIDs). FI-302 showed potent analgesic and antipyretic effects in the various models used. FI-302 showed an inhibitory effect on acute inflammatory response such as carrageenin-induced edema, but did not show any effect on chronic inflammatory response such as cotton pellet granuloma. These effects of FI-302 were about 2 to 7 times more potent than those of non-acidic NSAIDs such as mepirizole and tiaramide. Moreover, FI-302 had little or no ulcerogenic activity. From these results, it is conceivable that the spectrum of FI-302's activities is similar to those of non-acidic NSAIDs such as mepirizole and tiaramide. These results suggest that FI-302 is a new non-ulcerogenic anti-inflammatory compound, and should be suitably applicable for clinical purposes.
AuthorsT Kameyama, F Amanuma, S Okuyama, S Higuchi, H Aihara
JournalJournal of pharmacobio-dynamics (J Pharmacobiodyn) Vol. 8 Issue 6 Pg. 477-86 (Jun 1985) ISSN: 0386-846X [Print] Japan
PMID3877158 (Publication Type: Journal Article)
Chemical References
  • Anti-Inflammatory Agents, Non-Steroidal
  • Indoles
  • FI 302
Topics
  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal
  • Arthritis, Experimental (prevention & control)
  • Capillary Permeability
  • Edema (prevention & control)
  • Erythema (prevention & control)
  • Granuloma (prevention & control)
  • Guinea Pigs
  • Indoles (pharmacology)
  • Lethal Dose 50
  • Male
  • Mice
  • Rats
  • Rats, Inbred Strains
  • Stomach Ulcer (chemically induced)

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