Detection of antibody against extractable nuclear antigen by an enzyme-linked immuno-sorbent assay. Results from patients with rheumatic and internal medical diseases.
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| Abstract |
Anti-ENA antibody determination by ELISA technique may offer a valuable diagnostic help in the discrimination of patients with mixed connective tissue disease (MCTD) from those with other chronic inflammatory connective tissue diseases. Determination of this antibody was performed in a prospective designed investigation among 101 blood donors, 154 patients with various non-rheumatic internal medical diseases, and 229 patients with chronic inflammatory connective tissue diseases, including five patients with MCTD. A positive titre of anti-ENA antibody was found in approximately 10% of blood donors and patients with various internal medical disorders. A highly positive anti-ribonucleoprotein (RNP) titre was found in the patients with MCTD, but was also observed in patients with other chronic inflammatory connective tissue diseases, giving a predictive value of 56% for MCTD. We conclude that highly positive anti-RNP antibody values do not automatically indicate the diagnosis MCTD. Other diagnostic possibilities should still be considered.
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| Authors | J Struckmann, P Worning, R Manthorpe, G Bendixen |
| Journal | Allergy (Allergy) Vol. 40 Issue 6 Pg. 442-6 (Aug 1985) ISSN: 0105-4538 [Print] Denmark |
| PMID | 3876784 (Publication Type: Journal Article) |
| Chemical References |
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