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Zinc deficiency and blood lymphocyte function with sickle cell disease.

Abstract
A relationship between zinc deficiency and lymphocyte function in children with sickle cell disease (SCD) has been suggested. Number and function of B and T lymphocytes were assessed in 3 matched groups of children: normal subjects with Hb A and normal zinc; patients with SCD; and normal zinc (SCD-N); and patients with SCD and decreased zinc (SCD-D). Percentages of B and T cells, response to cutaneous antigens and increases in tetanus antibody titres were similar among all groups. Absolute numbers of WBC, lymphocytes and B and T cells were markedly increased in SCD-N (p less than 0.001) and to a lesser degree in SCD-D (p less than 0.01). Controls and SCD-N had a normal response to all mitogens, which was not inhibited by SCD-D sera. SCD-D had a depressed response to PHA (p less than 0.001), which was not corrected by zinc addition in vitro. These findings indicate that B cell function and T cell-dependent delayed hypersensitivity are normal in children with SCD and are independent of body zinc status. They also suggest some abnormality of T helper cells in the presence of zinc deficiency, and in the absence of a demonstrable serum inhibitor.
AuthorsC W Daeschner 3rd, U Carpentieri, A S Goldman, M E Haggard
JournalScandinavian journal of haematology (Scand J Haematol) Vol. 35 Issue 2 Pg. 186-90 (Aug 1985) ISSN: 0036-553X [Print] Denmark
PMID3876597 (Publication Type: Journal Article)
Chemical References
  • Immunoglobulin A
  • Immunoglobulin G
  • Immunoglobulin M
  • Mitogens
  • Tetanus Antitoxin
  • Zinc
Topics
  • Adolescent
  • Anemia, Sickle Cell (blood)
  • Antibody Formation
  • B-Lymphocytes (immunology)
  • Child
  • Child, Preschool
  • Female
  • Humans
  • Hypersensitivity, Delayed (immunology)
  • Immunoglobulin A (analysis)
  • Immunoglobulin G (analysis)
  • Immunoglobulin M (analysis)
  • Lymphocyte Activation (drug effects)
  • Male
  • Mitogens (pharmacology)
  • T-Lymphocytes (immunology)
  • Tetanus Antitoxin (analysis)
  • Zinc (deficiency)

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