Circulating Fc-receptor blocking factors in IgA nephropathies.

Abstract

Twenty-one patients with primary IgA nephropathy, 7 patients with Henoch-Schönlein nephritis and 4 patients with IgA nephropathy associated to alcoholic liver cirrhosis were tested for Fc-receptor phagocyte function by measuring the clearance of radiolabelled IgG-sensitized erythrocytes in vivo and the immune phagocytosis by monocytes in vitro. Meanwhile IgG-, IgA-, IgA1-, IgA2-, containing immune complexes, the complement components C3, C4, C3d and the HLA-A, B, DR phenotype were determined. The patients with major urinary abnormalities were well discriminated from those with only minimal hematuria by a defective macrophage function (p less than 0.01) and high levels of IgA immune complexes (p less than 0.02). Since non HLA-A, B, C, DR phenotype was prevalent in patients who had defective Fc-receptor function, whereas a significant correlation was found between Fc-receptor impairment and levels of IgA immune complexes, it appears likely that circulating blocking factors, possibly related to IgA containing immune materials, may impair macrophage function in IgA nephropathies.

• Authors: D Roccatello, R Coppo, G Piccoli, D Cordonnier, G Martina, C Rollino, G Picciotto, L M Sena, A Amoroso
• Journal: Clinical nephrology (Clin Nephrol) Vol. 23 Issue 4 Pg. 159-68 (Apr 1985) ISSN: 0301-0430 [Print] Germany
• PMID: 3874036 (Publication Type: Journal Article)

Chemical References

• Antigen-Antibody Complex
• Antigens, CD
• Complement C3
• Complement C4
• Fc(alpha) receptor
• Receptors, Fc
• Complement C3d

Topics

• Adolescent
• Adult
• Antigen-Antibody Complex (immunology)
• Antigens, CD
• Child
• Complement C3 (analysis)
• Complement C3d
• Complement C4 (analysis)
• Erythrocytes (immunology)
• Female
• Glomerulonephritis, IGA (immunology)
• Histocompatibility Testing
• Humans
• Macrophages (immunology)
• Male
• Middle Aged
• Monocytes (immunology)
• Nephritis (immunology)
• Phagocytosis
• Receptors, Fc (immunology)
• Rosette Formation