Treatment of lower urinary tract infections with single-dose trimethoprim-sulfamethoxazole.

Abstract

Two hundred three women from a primary care medical practice with symptoms of lower urinary tract infection and positive urine cultures were treated with trimethoprim-sulfamethoxazole. One hundred eleven women received a single dose and 92 were treated for ten days. Cure rates were 87 percent and 89 percent, respectively, one week after therapy. A narrow 95 percent confidence interval for the difference between the two cure rates (.02 +/- .09) suggests the treatments are equally effective. Patients were followed by chart audit and a self-reporting questionnaire. No difference in recurrence rates was found between the two groups six months after therapy. Single-dose trimethoprim-sulfamethoxazole is as effective as ten-day treatment in women with symptoms suggestive of lower urinary tract infection and has no greater relapse rate.

• Authors: R D Prentice, L R Wu, S H Gehlbach, J T Hanlon, N E Clapp-Channing, A L Finn
• Journal: The Journal of family practice (J Fam Pract) Vol. 20 Issue 6 Pg. 551-7 (Jun 1985) ISSN: 0094-3509 [Print] United States
• PMID: 3873511 (Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Infective Agents, Urinary
• Drug Combinations
• Trimethoprim, Sulfamethoxazole Drug Combination
• Trimethoprim
• Sulfamethoxazole

Topics

• Adult
• Aged
• Anti-Infective Agents, Urinary (administration & dosage, adverse effects)
• Bacterial Infections (drug therapy)
• Drug Administration Schedule
• Drug Combinations (administration & dosage, adverse effects)
• Drug Evaluation
• Female
• Follow-Up Studies
• Humans
• Middle Aged
• Random Allocation
• Recurrence
• Sulfamethoxazole (administration & dosage, adverse effects)
• Trimethoprim (administration & dosage, adverse effects)
• Trimethoprim, Sulfamethoxazole Drug Combination
• Urinary Tract Infections (drug therapy)