Single-dose therapy for cystitis in women. A comparison of trimethoprim-sulfamethoxazole, amoxicillin, and cyclacillin.

Abstract

We evaluated single-dose regimens of trimethoprim-sulfamethoxazole, amoxicillin, and cyclacillin as treatment for acute cystitis in 38 women. The trial was prematurely stopped because of frequent treatment failures. At two days after treatment, all 13 patients given trimethoprim-sulfamethoxazole were cured, while four (31%) of 13 given amoxicillin and four (33%) of 12 given cyclacillin had persistent bacteriuria. At two weeks, 11 (85%) of 13 patients given trimethoprim-sulfamethoxazole, six (50%) of 12 given amoxicillin, and three (30%) of ten given cyclacillin were cured. One patient with positive results of antibody-coated bacteria testing who was treated with cyclacillin had signs and symptoms of acute pyelonephritis three days after treatment, and two patients treated with amoxicillin and one treated with trimethoprim-sulfamethoxazole converted antibody-coated bacteria test results from negative to positive after therapy. We conclude that single-dose treatment of cystitis in unselected women with cyclacillin and amoxicillin may result in low cure rates and that progression to acute pyelonephritis may occur following ineffective single-dose therapy.

• Authors: T M Hooton, K Running, W E Stamm
• Journal: JAMA (JAMA) Vol. 253 Issue 3 Pg. 387-90 (Jan 18 1985) ISSN: 0098-7484 [Print] United States
• PMID: 3871233 (Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Drug Combinations
• Penicillins
• Cyclacillin
• Amoxicillin
• Trimethoprim, Sulfamethoxazole Drug Combination
• Trimethoprim
• Sulfamethoxazole

Topics

• Adolescent
• Adult
• Amoxicillin (administration & dosage, adverse effects, therapeutic use)
• Antibody-Coated Bacteria Test, Urinary
• Bacteriuria (drug therapy)
• Cyclacillin (administration & dosage, adverse effects, therapeutic use)
• Cystitis (complications, drug therapy)
• Drug Administration Schedule
• Drug Combinations (administration & dosage, adverse effects, therapeutic use)
• Female
• Humans
• Middle Aged
• Penicillins (therapeutic use)
• Pyelonephritis (etiology)
• Pyuria (drug therapy)
• Random Allocation
• Sulfamethoxazole (administration & dosage, adverse effects, therapeutic use)
• Trimethoprim (administration & dosage, adverse effects, therapeutic use)
• Trimethoprim, Sulfamethoxazole Drug Combination