Abstract |
1 The antihypertensive effect and tolerability of MK-196 (10 mg and 15 mg daily) was compared to hydrochlorothiazide (HCT; 50 mg daily) in a 4-week multiclinic, double-blind study involving 42 patients with mild to moderate, essential hypertension. 2 Both doses of MK-196 were as effective and sometimes more effective than HCT in lowering standing and supine systolic and diastolic blood pressures. 3 HCT consistently brought about significant increases in serum uric acid and significant decreases in serum potassium; both doses of MK-196 produced similar but less frequent and smaller changes in both of these parameters. 4 Both doses of MK-196 brought about significant decreases in body weight at Weeks 3 and 4 of drug treatment. 5 Patients taking MK-196 reported fewer adverse clinical reactions (10 mg = 15%; 15 mg = 13% than those taking HCT (21%). 6 MK-196 may offer a therapeutic advantage over HCT as an antihypertensive agent for use in the treatment of mild to moderate, essential hypertension.
|
Authors | C E Wilhelmsson, J A Vedin, C Moerlin, P Lund-Johansen, C Vorburger, W Enenkel, P M Lutterbeck, J Bolognese, V J Cirillo, K F Tempero |
Journal | British journal of clinical pharmacology
(Br J Clin Pharmacol)
Vol. 8
Issue 3
Pg. 261-6
(Sep 1979)
ISSN: 0306-5251 [Print] England |
PMID | 387057
(Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article, Randomized Controlled Trial)
|
Chemical References |
- Diuretics
- Indans
- Indenes
- Hydrochlorothiazide
- indacrinone
|
Topics |
- Adult
- Clinical Trials as Topic
- Diuretics
(adverse effects, therapeutic use)
- Double-Blind Method
- Female
- Humans
- Hydrochlorothiazide
(adverse effects, therapeutic use)
- Hypertension
(drug therapy, metabolism)
- Indans
(adverse effects, therapeutic use)
- Indenes
(therapeutic use)
- Male
- Middle Aged
- Time Factors
|