[On the molecular mechanism of action of (+)-cyanidanol-3 (author's transl)].

Abstract

The pharmacological actions of (+)-cyanidanol-3 [(+)-flavan-3,3',4',5,7-pentol, (+)-catechin, Catergen) in various experimental liver diseases are described according to the recent available literature. On this basis the hepatoprotective activity of the drug is due to its stabilizing effect on biological membranes and its specific inhibitory activity on the Fe-ADP-, CCl4- and CBrCl3- stimulated lipoperoxidation in vitro and in vivo.

• Authors: G Hennings
• Journal: Arzneimittel-Forschung (Arzneimittelforschung) Vol. 29 Issue 5 Pg. 720-4 ( 1979) ISSN: 0004-4172 [Print] Germany
• Vernacular Title: Zum molekularen Wirkungsmechanismus von (+)-Cyanidanol-3.
• PMID: 387044 (Publication Type: Journal Article, Review)

Chemical References

• Benzopyrans
• Lipid Peroxides
• Phalloidine
• Galactosamine
• Catechin

Topics

• Animals
• Benzopyrans (pharmacology)
• Catechin (pharmacology, therapeutic use)
• Chemical and Drug Induced Liver Injury (drug therapy, metabolism)
• Galactosamine (pharmacology)
• Lipid Peroxides (biosynthesis)
• Liver (drug effects, metabolism)
• Liver Diseases (drug therapy, metabolism)
• Membranes (drug effects)
• Phalloidine (poisoning)