Comparison of C-terminal and N-terminal PTH in secondary hyperparathyroidism in renal failure.

Abstract

In 89 patients with disorders in calcium regulation either C-terminal or N-terminal PTH or both, were elevated. In haemodialysis patients the results of C-terminal and N-terminal PTH measurements showed the same trend in 10 patients; in 30 patients only C-terminal and in four patients only N-terminal PTH was elevated. In patients with renal failure, creatinine clearance less than 30 ml/min, both C-terminal and N-terminal PTH were elevated in five patients, C-terminal PTH in 12 patients and N-terminal PTH in none of the patients studied. Fourteen patients with primary hyperparathyroidism were studied; in ten both C-terminal and N-terminal PTH were elevated, in two only C-terminal PTH and in another two only N-terminal PTH was elevated. The results show that there seems to be a better clinical correlation for hyperparathyroidism, in haemodialysis patients and patients with renal failure, using N-terminal PTH determinations rather than C-terminal PTH determinations, because in haemodialysis patients and patients with renal failure split products of the C-terminal region of PTH give unrealistically high PTH results.

• Authors: L Hortling, L Puutula-Räsänen, F Fyhrquist
• Journal: Scandinavian journal of urology and nephrology. Supplementum (Scand J Urol Nephrol Suppl) Vol. 90 Pg. 51-4 ( 1985) ISSN: 0300-8886 [Print] England
• PMID: 3868028 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Parathyroid Hormone
• Peptide Fragments
• amino-terminal parathyroid hormone
• carboxyl-terminal parathyroid hormone

Topics

• Humans
• Hyperparathyroidism (blood)
• Hyperparathyroidism, Secondary (blood)
• Kidney Failure, Chronic (blood)
• Parathyroid Hormone (blood)
• Peptide Fragments (blood)
• Radioimmunoassay
• Renal Dialysis