Double blind comparison between cimetidine and gefarnate in cases of duodenal ulcer.

Abstract

Thirty outpatients suffering from duodenal ulcer of recent onset were given cimetidine 1 g/day or gefarnate 250 mg/day for 6 weeks in a double blind trial, randomly balances between the groups. Endoscopic assessment was carried out at 4 and 6 weeks; patients healed after 4 weeks were withdrawn from the trial. In all parameters considered, cimetidine showed a highly significant difference. The healing rate at 4--6 weeks was 67--93% after cimetidine treatment and 27--53% after gefarnate treatment. The effect of cimetidine on the disappearance of symptoms, mainly the nocturnal ulcer pain, and on antacid consumption was greater than that after medication wity gefarnate. After 4--6 weeks of a full dose cimetidine regimen, both basal and pentagastrin stimulated gastric acid secretion were reduced and peptone meal stimulated serum gastrin increased; the basal gastrinaemia remained unchanged.

• Authors: M Cambielli, A Evangelista, M Guslandi, L Bierti, C Benvenuti, A Tittobello
• Journal: Acta hepato-gastroenterologica (Acta Hepatogastroenterol (Stuttg)) Vol. 26 Issue 4 Pg. 326-30 (Aug 1979) ISSN: 0300-970X [Print] Germany
• PMID: 386698 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Gastrins
• Guanidines
• Terpenes
• Gefarnate
• Cimetidine

Topics

• Adult
• Cimetidine (therapeutic use)
• Clinical Trials as Topic
• Double-Blind Method
• Duodenal Ulcer (blood, drug therapy)
• Female
• Gastric Juice (metabolism)
• Gastrins (blood)
• Gefarnate (therapeutic use)
• Guanidines (therapeutic use)
• Humans
• Male
• Middle Aged
• Terpenes (therapeutic use)
• Time Factors