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Poloxalene 2930, a hydrophobic surfactant that prevents atherosclerosis, alters composition of rabbit lipoproteins.

Abstract
Poloxalene 2930, a hydrophobic surfactant, was incorporated into an atherogenic diet at dose levels, 0.5% and 1% of the diet, and fed to rabbits for 10 weeks. Another group received plain atherogenic diet alone and a control group was fed chow. After this period, serum lipoproteins were separated by centrifugation and analyzed. The composition of lipoproteins from rabbits on atherogenic diet was abnormal. The cholesterol: triglyceride ratio of every lipoprotein fraction was significantly increased as was the cholesterol: protein ratio of very low density lipoproteins. Supplementing the diet with Poloxalene 2930 prevented these alterations. In all groups on the atherogenic diet the percentage of apolipoprotein E in VLDL and HDL increased. In the case of Poloxalene-treated rabbits this developed even though serum cholesterol levels were normal or slightly increased. It is concluded that Poloxalene 2930 has a systemic effect on lipoproteins which may contribute to its antiatherogenic action.
AuthorsB Kapuscinska, W J Bochenek, S K Peng, J B Rodgers
JournalAtherosclerosis (Atherosclerosis) Vol. 57 Issue 2-3 Pg. 149-58 (Nov 1985) ISSN: 0021-9150 [Print] Ireland
PMID3866581 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Apolipoproteins B
  • Apolipoproteins E
  • Blood Proteins
  • Cholesterol, LDL
  • Cholesterol, VLDL
  • Lipoproteins
  • Lipoproteins, VLDL
  • Triglycerides
  • Polyethylene Glycols
  • Poloxalene
  • Cholesterol
Topics
  • Animals
  • Apolipoproteins B (blood)
  • Apolipoproteins E (blood)
  • Arteriosclerosis (prevention & control)
  • Blood Proteins (metabolism)
  • Cholesterol (blood)
  • Cholesterol, LDL (blood)
  • Cholesterol, VLDL
  • Diet, Atherogenic
  • Lipoproteins (blood)
  • Lipoproteins, VLDL (blood)
  • Male
  • Poloxalene (pharmacology)
  • Polyethylene Glycols (pharmacology)
  • Rabbits
  • Triglycerides (blood)

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