Abstract |
Cefaclor given per os 20 mg/kg body weight was readily absorbed and distributed to adenoid tissue and to middle ear effusion in children with chronic OME. The levels obtained were above the MIC values of most strains of respiratory pathogens. The penetration characteristics were the same after the first and the 20th dose in a b.i.d. regimen. Elimination was completed within about 12 h. The double dose, 40 mg/kg body weight, did not give higher levels but a longer duration.
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Authors | S Ernstson, M Anari, T Edén, L Sundberg |
Journal | Acta oto-laryngologica. Supplementum
(Acta Otolaryngol Suppl)
Vol. 424
Pg. 7-12
( 1985)
ISSN: 0365-5237 [Print] Norway |
PMID | 3865494
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Adenoids
(metabolism)
- Cefaclor
(metabolism, therapeutic use)
- Cephalexin
(analogs & derivatives)
- Child
- Child, Preschool
- Chronic Disease
- Dose-Response Relationship, Drug
- Ear, Middle
(metabolism)
- Female
- Humans
- Infant
- Male
- Otitis Media with Effusion
(drug therapy, metabolism)
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