Abstract |
The immunological effect of lonazolac on mononuclear cell activation has been investigated using the indirect Leukocyte Adherence Inhibition Test in Arthritis. Under these conditions, the mononuclear cell response to a synovial stimulus can be abolished by very low concentrations of lonazolac, a new nonsteroidal antiinflammatory drug. This blockade can be completely released by the addition of prostaglandin E2. Lonazolac appears therefore as an agent able in addition to modulate the immune response.
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Authors | R Görtz, T Appelboom |
Journal | International journal of tissue reactions
(Int J Tissue React)
Vol. 7
Issue 4
Pg. 263-5
( 1985)
ISSN: 0250-0868 [Print] Switzerland |
PMID | 3864763
(Publication Type: Journal Article)
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Chemical References |
- Prostaglandins E
- Pyrazoles
- lonazolac
- Dinoprostone
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Topics |
- Arthritis
(immunology)
- Cell Adhesion
(drug effects)
- Dinoprostone
- Humans
- Kinetics
- Monocytes
(drug effects, immunology)
- Prostaglandins E
(pharmacology)
- Pyrazoles
(pharmacology)
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