Effect of oral penbutolol on renal haemodynamics of hypertensive patients with renal insufficiency.

Abstract

Acute or chronic administration of most beta-adrenoreceptor blocking drugs is associated with a fall in renal blood flow and glomerular filtration rate. In patients with renal insufficiency this effect on renal function may be clinically important. Penbutolol is a non-cardioselective, pure laevo, beta-blocker with intrinsic sympathomimetic activity. Previous studies have suggested that penbutolol may increase the glomerular filtration rate. In this study eight hypertensive patients with renal insufficiency were studied during a three-week placebo period and then for four weeks while taking penbutolol in a dose of 40 or 80 mg daily. Penbutolol produced a fall in the pulse rate in all eight patients. Five of the eight patients had a fall in their supine and standing blood pressure. Effective renal plasma flow and glomerular filtration rate did not change significantly. In seven of the eight patients there was a fall in the calculated renal vascular resistance but the mean fall did not reach statistical significance. Penbutolol appears to be an effective beta-blocker and one that could be used appropriately in patients with renal insufficiency.

• Authors: R R Bailey, R V Carlson, R J Walker, C P Swainson
• Journal: The New Zealand medical journal (N Z Med J) Vol. 98 Issue 785 Pg. 683-5 (Aug 28 1985) ISSN: 0028-8446 [Print] New Zealand
• PMID: 3863029 (Publication Type: Journal Article)

Chemical References

• Propanolamines
• Penbutolol

Topics

• Adult
• Female
• Hemodynamics (drug effects)
• Humans
• Hypertension (drug therapy)
• Kidney Diseases (drug therapy)
• Kidney Function Tests
• Male
• Middle Aged
• Penbutolol (administration & dosage, therapeutic use)
• Propanolamines (therapeutic use)