Topical retinoid treatment for dry eye disorders.

Abstract

We have demonstrated the clinical efficacy of topical all-trans retinoic acid ointment in the treatment of four severe cases of the following dry eye disorders: Keratoconjunctivitis sicca, Stevens-Johnson syndrome, drug-induced pseudopemphigoid, surgery-induced dry eye. In all four cases, impression cytology confirmed that improvements in symptoms, visual acuity, keratopathy, and Schirmer test resulted from reversal of the process of squamous metaplasia. This treatment represents the first nonsurgical approach with action directed specifically at the diseased ocular surface epithelia.

• Authors: S C Tseng
• Journal: Transactions of the ophthalmological societies of the United Kingdom (Trans Ophthalmol Soc U K (1962)) Vol. 104 ( Pt 4) Pg. 489-95 ( 1985) ISSN: 0078-5334 [Print] England
• PMID: 3862277 (Publication Type: Case Reports, Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Tretinoin

Topics

• Administration, Topical
• Adult
• Aged
• Conjunctiva (pathology)
• Cornea (pathology)
• Female
• Humans
• Keratoconjunctivitis (drug therapy)
• Male
• Metaplasia (prevention & control)
• Pemphigoid, Bullous (drug therapy)
• Stevens-Johnson Syndrome (drug therapy)
• Tretinoin (administration & dosage, therapeutic use)
• Xerophthalmia (drug therapy, pathology)