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Clonal development from a progenitor with restricted differentiative expression in acute lymphoblastic leukemia.

Abstract
Three patients with acute lymphoblastic leukemia (ALL) and heterozygous for the Mediterranean variant of glucose-6-phosphate dehydrogenase (G6PD) have been investigated with the 2-deoxyglucose-6-phosphate (2dG6P) method to determine the number and type of progenitor cells in which the disease arose. A monoclonal origin was established for the lymphoblasts, while the other hemopoietic cell lines were not involved in the leukemic process.
AuthorsA M Ferraris, L Canepa, L Massimo, G Dini, G Broccia, T Meloni, G Forteleoni, C Melani, G F Gaetani
JournalAmerican journal of hematology (Am J Hematol) Vol. 20 Issue 1 Pg. 81-3 (Sep 1985) ISSN: 0361-8609 [Print] United States
PMID3861091 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Deoxyglucose
  • Glucosephosphate Dehydrogenase
Topics
  • Child
  • Child, Preschool
  • Deoxyglucose (metabolism)
  • Female
  • Glucosephosphate Dehydrogenase (genetics)
  • Heterozygote
  • Humans
  • Leukemia, Lymphoid (genetics)
  • Middle Aged
  • Neoplastic Stem Cells
  • Stem Cells

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