Combination chemotherapy for multiple myeloma with BCNU, cyclophosphamide, vincristine, melphalan, and prednisone (M-2 protocol).

54 consecutively referred, previously untreated patients with stage II and III multiple myeloma have been treated with the M-2 protocol. 50% of patients had a performance status of less than 50%. 13% were stage II and 87% stage III. In 50 of 54 patients (90%), and objective response according to the Myeloma Task Force was achieved; 10% of the responses have been complete (9+, 15+, 17+, 18+ and 66+ months). Remissions now range from 1 to 86+ months. The actuarial median survival determined from the initiation of therapy will exceed 4 years. Toxicity was acceptable with mild myelosuppression. These results confirm the efficacy of the M-2 protocol in multiple myeloma with regards to response rate and survival.
AuthorsD C Case Jr, H L Sonneborn, S D Paul, D M Hayes, B M Dorsk, R J Carroll, L Bove
JournalOncology (Oncology) Vol. 42 Issue 3 Pg. 137-40 ( 1985) ISSN: 0030-2414 [Print] SWITZERLAND
PMID3858763 (Publication Type: Journal Article)
Chemical References
  • Immunoglobulins
  • Myeloma Proteins
  • Vincristine
  • Cyclophosphamide
  • Melphalan
  • Carmustine
  • Prednisone
  • Adult
  • Aged
  • Antineoplastic Combined Chemotherapy Protocols
  • Blood Urea Nitrogen
  • Carmustine (adverse effects, therapeutic use)
  • Cyclophosphamide (adverse effects, therapeutic use)
  • Humans
  • Immunoglobulins (analysis)
  • Leukemia, Monocytic, Acute (chemically induced)
  • Melphalan (adverse effects, therapeutic use)
  • Middle Aged
  • Multiple Myeloma (drug therapy)
  • Myeloma Proteins (analysis)
  • Prednisone (adverse effects, therapeutic use)
  • Prognosis
  • Time Factors
  • Vincristine (adverse effects, therapeutic use)

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