Inhibition of Friend cell erythrodifferentiation by modification of membrane phospholipid composition by choline analogues.

Abstract

Dimethylsulfoxide-stimulated Friend leukemia cell erythrodifferentiation was inhibited by choline analogues such as N-monomethylethanolamine and N,N-dimethylethanolamine. Phosphatidyl-N-monomethylethanolamine and phosphatidyl-N,N-dimethylethanolamine were then accumulated in the cell membranes. N-Monomethylethanolamine also inhibited Friend leukemia cell erythrodifferentiation stimulated by hexamethylene bisacetamide and N-methylacetamide, but did not inhibit differentiation induced by sodium butyrate. This inhibitory effect of N-monomethylethanolamine was partially abrogated by spermine.

• Authors: S Kaiho, K Mizuno
• Journal: Biochimica et biophysica acta (Biochim Biophys Acta) Vol. 838 Issue 1 Pg. 175-8 (Jan 28 1985) ISSN: 0006-3002 [Print] Netherlands
• PMID: 3855361 (Publication Type: Journal Article)

Chemical References

• Ethanolamines
• Phosphatidylethanolamines
• Phospholipids
• phosphatidyl-N-monomethylaminoethanol
• phosphatidyldimethylethanolamine
• Deanol
• Choline
• Dimethyl Sulfoxide
• N-methylaminoethanol

Topics

• Animals
• Cell Differentiation (drug effects)
• Cell Line
• Choline (analogs & derivatives)
• Deanol (pharmacology)
• Dimethyl Sulfoxide (pharmacology)
• Erythrocyte Membrane (drug effects, metabolism)
• Ethanolamines (pharmacology)
• Friend murine leukemia virus
• Leukemia, Erythroblastic, Acute (metabolism, pathology)
• Phosphatidylethanolamines (blood)
• Phospholipids (blood)