[Comparative clinical study of aspoxicillin and sulbenicillin in postoperative wound infections].

Abstract

A well-controlled comparative study was performed to evaluate efficacy, safety and utility of aspoxicillin (ASPC) as compared with sulbenicillin (SBPC) in the treatment of postoperative wound infections. Either 2 g of ASPC or 2 g of SBPC was administered to patients by intravenous drip infusion twice a day for 7 days. The following results were obtained: Overall clinical effectiveness rates were 82.5% (66/80) in ASPC group and 77.0% (57/74) in SBPC group, with no statistically significant difference between 2 groups. Final overall clinical improvement rates were 83.8% (67/80) in ASPC group and 81.1% (60/74) in SBPC group, with no statistically significant difference between 2 groups. As to bacteriological effectiveness, eradication rates of clinical isolates were 70.4% (38/54) in ASPC group and 74.4% (32/43) in SBPC group. There was no statistically significant difference in 2 groups. Side effects and abnormal laboratory findings were observed in 6 cases (6.7%) and 11 cases (12.4%) in ASPC group (89 cases) respectively, and 4 cases (4.4%) and 7 cases (7.8%) in SBPC group (90 cases) respectively. Especially severe adverse reactions were not observed, and there was no significant difference in the incidences of side effects and abnormal laboratory findings between 2 groups. As to overall clinical utility, utility rates were 77.5% (62/80) in ASPC group and 70.3% (52/74) in SBPC group. There was no statistically significant difference between 2 groups. These results may be indicated that ASPC is as useful as SBPC in the treatment of postoperative wound infections.

• Authors: J Yura, N Shinagawa, S Ishikawa, T Sakabe, S Iwai, T Sato, K Sakai, M Fujimoto, T Ueda, K Orita
• Journal: The Japanese journal of antibiotics (Jpn J Antibiot) Vol. 38 Issue 9 Pg. 2417-43 (Sep 1985) ISSN: 0368-2781 [Print] Japan
• PMID: 3852899 (Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, English Abstract, Journal Article)

Chemical References

• aspoxicillin
• Amoxicillin
• Sulbenicillin
• Penicillin G

Topics

• Adolescent
• Adult
• Aged
• Amoxicillin (adverse effects, analogs & derivatives, pharmacology, therapeutic use)
• Drug Evaluation
• Female
• Gram-Negative Bacteria (drug effects)
• Gram-Positive Bacteria (drug effects)
• Humans
• Infusions, Parenteral
• Male
• Middle Aged
• Penicillin G (analogs & derivatives)
• Penicillin Resistance
• Random Allocation
• Sulbenicillin (adverse effects, pharmacology, therapeutic use)
• Surgical Wound Infection (drug therapy)