Efficacy of
kanamycin,
ampicillin and their combinations with methyluracyl and
pyrogenal in experimental Coli
infections was studied. The
antibiotics were administered an hour after the
infection. Methyluracyl and
pyrogenal were used according to 2 schemes. Scheme No. I: the
drug is used daily for 7 days in increasing doses, the last dose is administered 24 hours before the
infection. Scheme No. 2: the
drug is used once at the moment of the
infection. The methyluracyl doses were: 0.5, 1.0, 2.5 mg and 5 mg and 5 mg per a mouse during the following 4 days. The pyrrogenal doses were: 5, 10, 15, 25, 30 and 35 minimum pyrogenic doses. 5 mg of methyluracyl and 35 minimum pyrogenic doses of
pyrogenal were used according to scheme No. 2. The most pronounced increase in the efficacy of
kanamycin,
ampicillin and their combination was observed in the animals treated simultaneously with methyluracyl and
pyrogenal according to scheme No. 1. The efficacy of
kanamycin and
ampicillin increased 3 and 2.68 times respectively. ED50 of
kanamycin and
ampicillin used in combination in the animals treated with methyluracyl and
pyrogenal was lowered 4 and 2.9 times respectively as compared to that in the animal groups treated only with the
antibiotic combination and 21 and 15.2 times respectively when the
antibiotics were used alone. Sanation of the animal organs was also rather successful. A single administration of methyluracyl and
pyrogenal simultaneously with the
infection (scheme No. 2) had a lower effect on the efficacy.