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Substituted 2-pyrones, 2-pyridones, and other congeners of elasnin as potential agents for the treatment of chronic obstructive lung diseases.

Abstract
Several congeners of elasnin (I) have been synthesized and shown to inhibit human leukocyte elastase (HLE). The C-3 alkyl substituted 2-pyrones 11 and 12 were found to be the most effective inhibitors of the enzyme. These compounds are highly specific in their inhibitory activity.
AuthorsW C Groutas, M A Stanga, M J Brubaker, T L Huang, M K Moi, R T Carroll
JournalJournal of medicinal chemistry (J Med Chem) Vol. 28 Issue 8 Pg. 1106-9 (Aug 1985) ISSN: 0022-2623 [Print] United States
PMID3848491 (Publication Type: Comparative Study, Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Pyridones
  • Elastin
  • Pancreatic Elastase
Topics
  • Elastin (pharmacology)
  • Humans
  • In Vitro Techniques
  • Leukocytes (enzymology)
  • Lung Diseases, Obstructive (drug therapy)
  • Pancreatic Elastase (antagonists & inhibitors)
  • Pyridones (chemical synthesis, pharmacology)
  • Structure-Activity Relationship

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