Abstract |
Several congeners of elasnin (I) have been synthesized and shown to inhibit human leukocyte elastase (HLE). The C-3 alkyl substituted 2-pyrones 11 and 12 were found to be the most effective inhibitors of the enzyme. These compounds are highly specific in their inhibitory activity.
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Authors | W C Groutas, M A Stanga, M J Brubaker, T L Huang, M K Moi, R T Carroll |
Journal | Journal of medicinal chemistry
(J Med Chem)
Vol. 28
Issue 8
Pg. 1106-9
(Aug 1985)
ISSN: 0022-2623 [Print] United States |
PMID | 3848491
(Publication Type: Comparative Study, Journal Article, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Pyridones
- Elastin
- Pancreatic Elastase
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Topics |
- Elastin
(pharmacology)
- Humans
- In Vitro Techniques
- Leukocytes
(enzymology)
- Lung Diseases, Obstructive
(drug therapy)
- Pancreatic Elastase
(antagonists & inhibitors)
- Pyridones
(chemical synthesis, pharmacology)
- Structure-Activity Relationship
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