In vitro studies using ion exchange resins as potential phosphate binders for renal failure patients.

Abstract

The uptake of phosphate [expressed as phosphorus (P)] by the anion exchange resins, Dowex 1-X8, Dowex SBR, and Bio-Rex 5, aluminum hydroxide, and sucralfate tablets was evaluated. The maximum uptake capacities (in mg P per gram of "wet" resin or solid) were 56, 49, and 84 mg for Dowex SBR, Dowex 1-X8, and Bio-Rex 5 resins, respectively, and 164-168 mg for aluminum hydroxide and sucralfate. At a concentration of P considered to approximate that encountered in the stomach (0.3 mg/ml), Bio-Rex 5 resin, aluminum hydroxide, and sucralfate bound similar amounts of P. Physiologic concentrations of bicarbonate or chloride and simulated gastric or intestinal fluids caused small changes in P uptake by Bio-Rex 5 resin. The resins bound large quantities of taurocholic (TA) and glycocholic (GA) acids. However, when Bio-Rex 5 was converted to the taurocholate form, it bound the same amount of P as the original chloride-form resin, and the binding of TA was prevented.

• Authors: H M Burt, E C Cameron, M Leung, H Erber, J D Price
• Journal: Uremia investigation (Uremia Invest) 1985-1986 Vol. 9 Issue 1 Pg. 35-44 ISSN: 0740-1353 [Print] United States
• PMID: 3841765 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anion Exchange Resins
• Ion Exchange Resins
• Phosphates
• Resins, Synthetic
• Phosphorus
• Dowex
• Sucralfate
• Taurocholic Acid
• Aluminum Hydroxide
• Aluminum
• Glycocholic Acid
• sodium phosphate

Topics

• Aluminum (metabolism)
• Aluminum Hydroxide (metabolism)
• Anion Exchange Resins (metabolism)
• Gastric Juice (metabolism)
• Glycocholic Acid (metabolism)
• Humans
• In Vitro Techniques
• Ion Exchange Resins (metabolism)
• Phosphates (metabolism)
• Phosphorus (metabolism)
• Regression Analysis
• Resins, Synthetic
• Sucralfate
• Taurocholic Acid (metabolism)