[Antiarrhythmic action of 3-carbethoxyamino-5-dimethylaminoacetyl-iminodibenzyl hydrochloride (Bonnecor, AWD 19-166, GS -15) on experimental arrhythmia induced by aconitin, ouabain, calcium chloride and barium chloride].

Abstract

In comparison with detajmium, prajmalium, ajmaline, quinidine, lidocaine, disopyramide, propranolol, and Ethmozin the substance GS 015 is tested on the aconitin-induced arrhythmia of the rat, the auricular fibrillation by aconitin of the dog, the ventricular arrhythmia induced by ouabaine of the dog, the arrhythmia caused by calcium chloride of the rat, and the arrhythmia induced by barium chloride of the rabbit. The particular qualities of effect in the special forms of arrhythmia are discussed in connection with the study of the antiarrhythmic action in case of coronary occlusion, with the increase of the electric fibrillatory threshold, and with the electrophysiologic tests.

• Authors: K Femmer, H Poppe, S Heer, R Bartsch
• Journal: Die Pharmazie (Pharmazie) Vol. 40 Issue 12 Pg. 836-40 (Dec 1985) ISSN: 0031-7144 [Print] Germany
• Vernacular Title: Zur antiarrhythmischen Wirkung von 3-carbethoxyamino-5-dimethylaminoacetyl-iminodibenzyl-hydrochlorid (Bonnecor, AWD 19-166, GS 015) an der experimentellen Arrhythmie durch Aconitin, Ouabain, Calciumchlorid und Bariumchlorid.
• PMID: 3841597 (Publication Type: English Abstract, Journal Article)

Chemical References

• Anti-Arrhythmia Agents
• Barium Compounds
• Chlorides
• Dibenzazepines
• barium chloride
• Barium
• Ouabain
• Strophanthidin
• tiracizine
• Calcium Chloride
• Aconitine

Topics

• Aconitine
• Animals
• Anti-Arrhythmia Agents (pharmacology)
• Arrhythmias, Cardiac (chemically induced)
• Barium
• Barium Compounds
• Calcium Chloride
• Chlorides
• Dibenzazepines (pharmacology)
• Dogs
• Heart Rate (drug effects)
• Ouabain
• Rabbits
• Rats
• Strophanthidin (pharmacology)