Synthesis and biological activity of (7S)-O-epoxyalkyl derivatives of daunomycinone.

Abstract

Synthesis and antibacterial activity of a number of 7-O-epoxyalkyl derivatives of daunomycinone prepared from 7-O-alkenyl derivatives of daunomycinone are described along with their inhibitory effect on leukemia P 388 cells.

• Authors: V Prikrylová, H Lipavská, J V Jizba, J Fuska, M Podojil, Z Vanĕk
• Journal: The Journal of antibiotics (J Antibiot (Tokyo)) Vol. 38 Issue 12 Pg. 1714-8 (Dec 1985) ISSN: 0021-8820 [Print] England
• PMID: 3841537 (Publication Type: Journal Article)

Chemical References

• Antibiotics, Antineoplastic
• Naphthacenes
• daunomycinone

Topics

• Animals
• Antibiotics, Antineoplastic (chemical synthesis, pharmacology)
• Bacteria (drug effects)
• Leukemia P388 (metabolism)
• Naphthacenes (chemical synthesis, pharmacology)