The anticoagulant effect of prolame, N-(3-hydroxy-1,3,5(10)estratrien-17 beta-yl)-3-hydroxypropylamine, a novel amino-estrogen.

Abstract

The anticoagulant and estrogenic effects of prolame, N-(3-hydroxy-1,3,5(10)-estratrien-17 beta-yl)-3-hydroxypropylamine, are described. A single subcutaneous injection of prolame in male mice, ovariectomized mice, adult and infant male rats, produced dose-dependent increases of blood clotting time, which could be observed with the larger doses even after 4 days. In ovariectomized mice, prolame produced vaginal cornifications of shorter duration than those produced by estradiol-17 beta. The evidence suggests that, in contrast with currently used estrogens, prolame would not generate cardiovascular accidents if used for the treatment of prostatic carcinoma; it could also be exceptionally effective for the prevention of thrombosis.

• Authors: C Rubio-Póo, J J Mandoki, N Mendoza-Patiño, C Lemini, A de la Peña, F Cruz, E Zavala, G Silva, J Garcia-Mondragón, J M Fernández
• Journal: Steroids (Steroids) Vol. 45 Issue 2 Pg. 159-70 (Feb 1985) ISSN: 0039-128X [Print] United States
• PMID: 3841425 (Publication Type: Journal Article)

Chemical References

• Anticoagulants
• Coagulants
• Convulsants
• Estradiol Congeners
• Estrenes
• prolame

Topics

• Animals
• Anticoagulants
• Coagulants (pharmacology)
• Convulsants (pharmacology)
• Dose-Response Relationship, Drug
• Estradiol Congeners
• Estrenes (pharmacology)
• Female
• Male
• Mice
• Mice, Inbred Strains
• Rats
• Rats, Inbred Strains
• Time Factors
• Vagina (drug effects)