HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Effect of a new hypoglycemic agent (MDL-310) on glucose metabolism.

Abstract
N-[3-(dimethylamino)-2-propoxy-2-propenylidene]- N-methylmethanaminium as the iodide or camsylate salt (MDL-310) is a newly reported chemical which has been shown to produce hypoglycemia in vivo. The studies reported here describe in vivo and in vitro effects of MDL-310 on carbohydrate metabolism. In nonfasted mice, MDL-310 decreased liver glycogen and then produced hypoglycemia, concomitant with a near total depletion of liver glycogen stores. In fasted rats, nonhypoglycemic doses of MDL-310 increased glucose production and utilization as determined by tracer studies with [6-3H]glucose. Hypoglycemic doses decreased glucose production and increased blood lactate, which suggests an inhibition of gluconeogenesis. In isolated rat hepatocytes MDL-310, at concentrations of greater than or equal to 5 X 10(-6) M, inhibited gluconeogenesis from lactate (10 mM) plus pyruvate (2 mM). We conclude that the primary action of MDL-310 is to increase glucose utilization and that decreased production due to the inhibition of gluconeogenesis is involved in the hypoglycemic action. A single metabolic action of MDL-310 to increase glycolytic metabolism of glucose is proposed which could explain both the increase in glucose utilization and decrease in glucose production.
AuthorsK M Robinson, A J Payne, S L Zehr, B L Rhinehart
JournalThe Journal of pharmacology and experimental therapeutics (J Pharmacol Exp Ther) Vol. 235 Issue 3 Pg. 571-6 (Dec 1985) ISSN: 0022-3565 [Print] United States
PMID3841154 (Publication Type: Journal Article)
Chemical References
  • Hypoglycemic Agents
  • Lactates
  • Quaternary Ammonium Compounds
  • Lactic Acid
  • Glycogen
  • MDL 310
  • Glucose
Topics
  • Animals
  • Dose-Response Relationship, Drug
  • Gluconeogenesis (drug effects)
  • Glucose (metabolism)
  • Glycogen (metabolism)
  • Hypoglycemic Agents (pharmacology)
  • In Vitro Techniques
  • Lactates (blood)
  • Lactic Acid
  • Liver (metabolism)
  • Male
  • Mice
  • Mice, Inbred ICR
  • Quaternary Ammonium Compounds (pharmacology)
  • Rats
  • Rats, Inbred Strains

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: