Increase of the ventricular fibrillation threshold by 711389-S, a new antiarrhythmic agent, in guinea-pigs.

Abstract

The increase of the ventricular fibrillation threshold (VFT) by 711389-S, a new antiarrhythmic agent, was compared with several other antiarrhythmic drugs using both in vitro (Langendorff) and in vivo preparations of guinea-pigs. The doses of antiarrhythmic drugs for increasing VFT by 10 volts in in vitro (microgram) and in vivo (mg/kg, i.v.) preparations were as follows: 711389-S: 4.2, 0.15; disopyramide: 32.6, 0.86; quinidine: 32.0, 0.57; aprindine: 7.6, 0.55; propranolol: 16.6, 0.57; and lidocaine: 20.7, 1.52. The duration of the antifibrillatory effects of 711389-S almost corresponded with those of aprindine and propranolol.

• Authors: S Nakajima, M Ueda
• Journal: Japanese journal of pharmacology (Jpn J Pharmacol) Vol. 38 Issue 4 Pg. 436-8 (Aug 1985) ISSN: 0021-5198 [Print] Japan
• PMID: 3840850 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Anti-Arrhythmia Agents
• Propanolamines
• 711389-S

Topics

• Action Potentials (drug effects)
• Animals
• Anti-Arrhythmia Agents (pharmacology)
• Dose-Response Relationship, Drug
• Guinea Pigs
• Heart (drug effects)
• In Vitro Techniques
• Male
• Propanolamines (pharmacology)
• Ventricular Fibrillation (physiopathology)