Potentiation of the anthelmintic activity of oxfendazole by parbendazole.

Abstract

The ability of parbendazole (PBZ) to potentiate co-administered oxfendazole (OFZ) was investigated. Administration of a range (1.35-36.0 mg/kg) of doses of PBZ with 4.53 mg OFZ/kg demonstrated that significant potentiation occurred at 4.5 mg PBZ/kg. At 4.5 mg PBZ/kg, the area under the plasma OFZ concentration curve was about twice that obtained from oral administration of OFZ alone. When tested against benzimidazole-resistant Haemonchus contortus and Trichostrongylus colubriformis, the mixture of 4.5 mg PBZ + 4.53 mg OFZ/kg was significantly more effective than 4.53 mg OFZ/kg alone, and PBZ alone showed no activity against these resistant nematodes. The demonstration of PBZ-OFZ potentiation has indicated a means of obtaining a more effective use of currently available anthelmintics in the treatment of helminthiasis.

• Authors: D R Hennessy, E Lacey, R K Prichard, J W Steel
• Journal: Journal of veterinary pharmacology and therapeutics (J Vet Pharmacol Ther) Vol. 8 Issue 3 Pg. 270-5 (Sep 1985) ISSN: 0140-7783 [Print] England
• PMID: 3840535 (Publication Type: Journal Article)

Chemical References

• Anthelmintics
• Benzimidazoles
• parbendazole
• oxfendazole

Topics

• Animals
• Anthelmintics (pharmacology)
• Benzimidazoles (blood, pharmacology, therapeutic use)
• Chromatography, High Pressure Liquid
• Drug Synergism
• Kinetics
• Male
• Nematode Infections (drug therapy, veterinary)
• Plasma (metabolism)
• Sheep (blood)
• Sheep Diseases (drug therapy)