Laboratory evaluation of a new long-acting 3-azinomethylrifamycin FCE 22250.

Abstract	FCE 22250 (3-(N-piperidinomethylazino)methylrifamycin SV) is a member of the new class of 3-azinomethylrifamycins characterized by a long persistance in animals, a good oral absorption and a broad antibacterial spectrum including mycobacteria. In the experimental mice infection sustained by Mycobacterium tuberculosis H37Rv, FCE 22250 shows an efficacy 14 times higher than rifampicin and is still therapeutic when administered once every three weeks.
Authors	C Della Bruna, D Ungheri, G Sebben, A Sanfilippo
Journal	The Journal of antibiotics (J Antibiot (Tokyo)) Vol. 38 Issue 6 Pg. 779-86 (Jun 1985) ISSN: 0021-8820 [Print] England
PMID	3839503 (Publication Type: Journal Article)
Chemical References	Rifamycins FCE 22250
Topics	Animals Dogs Female Kinetics Mice Mice, Inbred Strains Microbial Sensitivity Tests Mycobacterium (drug effects) Rats Rifamycins (metabolism, pharmacology) Tissue Distribution

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