[Dehydration of aklavinone, PMR spectra of aklavinone and its dehydration products].

Abstract

The PMR 1H spectra of aklavinone, monoanhydroaklavinone and bisanhydroaklavinone were completely assigned with the use of the double resonance technique and the method of resolution enhancement (multiplication of the free induction decay by the Gauss function). It was shown that under mild conditions in the presence of hydrazine, aklavinone dehydrated at the C9-C10 bond and transformed into monoanhydroaklavinone. Under less mild conditions when akalavinone was heated at 250 degrees C, dehydration proceeded at the C9-C10 and C7-C8 bonds to form bisanhydroaklavinone.

• Authors: S V Shorshnev, V S Soĭfer, A I Chernyshev
• Journal: Antibiotiki i meditsinskaia biotekhnologiia = Antibiotics and medical biotechnology (Antibiot Med Biotekhnol) Vol. 30 Issue 3 Pg. 171-3 (Mar 1985) ISSN: 0233-7525 [Print] Russia (Federation)
• Vernacular Title: Degidratatsiia aklavinona, spektry PMR aklavinona i produktov ego degidratatsii.
• PMID: 3839354 (Publication Type: English Abstract, Journal Article)

Chemical References

• Anthracyclines
• Antibiotics, Antineoplastic
• Naphthacenes
• bis(anhydro)aklavinone
• aklavinone
• monoanhydroaklavinone

Topics

• Anthracyclines
• Antibiotics, Antineoplastic
• Chemical Phenomena
• Chemistry
• Hot Temperature
• Magnetic Resonance Spectroscopy
• Naphthacenes (analysis)