Hb Regina or alpha 2 beta 2 96(FG3)Leu----Val: a high oxygen affinity variant discovered by cation-exchange HPLC.

Abstract

Results are reported of studies of the hemoglobin from one member of a Canadian family with a mild erythrocytosis. This variant, which accounted for about 40% of the hemoglobin, could be separated from Hb A and Hb A2 by cation-exchange chromatography. Micro methodology allowed the characterization of a Leu----Val replacement at position beta 96(FG3). Hb Regina has an increased oxygen affinity, which adequately explains the hematological observations.

• Authors: R Devaraj, J B Wilson, T H Huisman
• Journal: American journal of hematology (Am J Hematol) Vol. 19 Issue 2 Pg. 195-200 (Jun 1985) ISSN: 0361-8609 [Print] United States
• PMID: 3839106 (Publication Type: Case Reports, Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Hemoglobins, Abnormal
• Peptide Fragments
• hemoglobin Regina
• Oxygen

Topics

• Adult
• Amino Acid Sequence
• Chromatography, High Pressure Liquid
• Hemoglobins, Abnormal (isolation & purification, metabolism)
• Humans
• Male
• Oxygen (blood)
• Peptide Fragments (isolation & purification)
• Polycythemia (blood)