Urinary hypoxanthine and pseudouridine as indicators of tumor development in mesothelioma-transplanted nude mice.

Abstract

A human mesothelioma was heterotransplanted to nude mice, and the urinary excretions of hypoxanthine, xanthine, pseudouridine, orotic acid, 7-methylguanine, and 1-methylhypoxanthine have been followed before and after the tumor transplantation. The compounds were measured by means of isotachophoresis, which has been found a rapid and precise method. The tumor reached maximum size within 30 days, and at this time a significantly increased excretion of pseudouridine and hypoxanthine was observed. Tumor growth was stopped by chemotherapy (vincristine, cyclophosphamide, prednisolone, and Adriamycin), and corresponding to this, a decrease occurred in both pseudouridine and hypoxanthine excretion to normal values.

• Authors: L Buhl, C Dragsholt, P Svendsen, E Hage, M R Buhl
• Journal: Cancer research (Cancer Res) Vol. 45 Issue 3 Pg. 1159-62 (Mar 1985) ISSN: 0008-5472 [Print] United States
• PMID: 3838262 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Hypoxanthines
• Pseudouridine
• Hypoxanthine
• Vincristine
• Doxorubicin
• Cyclophosphamide
• Prednisolone
• Uridine

Topics

• Animals
• Antineoplastic Combined Chemotherapy Protocols
• Cyclophosphamide (therapeutic use)
• Doxorubicin (therapeutic use)
• Female
• Hypoxanthine
• Hypoxanthines (urine)
• Male
• Mesothelioma (drug therapy, pathology, urine)
• Mice
• Mice, Nude
• Neoplasm Transplantation
• Prednisolone (therapeutic use)
• Pseudouridine (urine)
• Uridine (analogs & derivatives)
• Vincristine (therapeutic use)