[Fundamental and clinical studies of aztreonam in the field of obstetrics and gynecology].

Abstract

Aztreonam (AZT, E-0734), a new beta-lactam antibiotic, was fundamentally and clinically studied. The following results were obtained. The serum and internal genital tissue levels for AZT after 1 g intravenous injection had been kept at more than about 20 micrograms/ml and 3.0 micrograms/g, respectively, during 1 hour. AZT was administered at 1-2 g of daily dose by intravenous injection or intravenous drip infusion to 5 patients with obstetric and gynecological infections, comprising 1 of pyometra, parametritis, Bartholin's abscess, puerperal endometritis and diffuse peritonitis. Clinical efficacy was; excellent in 1 puerperal endometritis case, good in 2 cases and poor in 2 cases. Neither side effect nor abnormal laboratory finding was observed.

• Authors: E Ushioda, H Iioka, I Shimamoto, M Ichijo
• Journal: The Japanese journal of antibiotics (Jpn J Antibiot) Vol. 38 Issue 12 Pg. 3645-50 (Dec 1985) ISSN: 0368-2781 [Print] Japan
• PMID: 3834150 (Publication Type: English Abstract, Journal Article)

Chemical References

• Aztreonam

Topics

• Adult
• Aged
• Aztreonam (administration & dosage, metabolism)
• Bacterial Infections (drug therapy)
• Drug Evaluation
• Female
• Genital Diseases, Female (drug therapy)
• Genitalia, Female (metabolism)
• Humans
• Infusions, Parenteral
• Injections, Intravenous
• Middle Aged
• Pregnancy
• Puerperal Infection (drug therapy)