Interaction of antidepressants with antiparkinsonian agents in rats.

Abstract

The influence of antidepressants: nomifensine, imipramine, amitriptyline and trazodone on the effect of antiparkinsonian agents: trihexyphenidil and L-DOPA + carbidopa mixture (sinemet) in the model of haloperidol catalepsy was investigated in rats. In some experiments deprenyl, a selective MAO-B inhibitor, was used. It was found that antidepressant drugs in doses not influencing haloperidol catalepsy enhanced significantly the anticataleptic effect of trihexyphenidil and L-DOPA + carbidopa. The most effective in the interaction with both antiparkinsonian agents was nomifensine. Imipramine and trazodone potentiated anticataleptic effect of L-DOPA + carbidopa more strongly than those of trihexyphenidil. The most potent anticataleptic effect was observed after combined treatment of rats with deprenyl and L-DOPA + carbidopa.

• Authors: I Zebrowska-Lupina, A Porowska, T Pietrasiewicz
• Journal: Polish journal of pharmacology and pharmacy (Pol J Pharmacol Pharm) 1985 Nov-Dec Vol. 37 Issue 6 Pg. 865-74 ISSN: 0301-0244 [Print] Poland
• PMID: 3832020 (Publication Type: Journal Article)

Chemical References

• Antidepressive Agents
• Antiparkinson Agents
• Levodopa
• Trihexyphenidyl
• Haloperidol

Topics

• Animals
• Antidepressive Agents (pharmacology)
• Antiparkinson Agents (pharmacology)
• Catalepsy (chemically induced, prevention & control)
• Drug Interactions
• Haloperidol (pharmacology)
• Levodopa (pharmacology)
• Male
• Rats
• Rats, Inbred Strains
• Time Factors
• Trihexyphenidyl (pharmacology)