Abstract |
The emulsifier Atlox was capable of enhancing the infectivity of influenza virus in Chang human conjunctiva cells. Prior to infection, pre-treatment of cells with 2.5 to 10 ppm of Atlox for 6 to 8 h was necessary to detect an increase in virus production. Although there was no difference in the amount of adsorbed virus, the number of successfully infected cells was at least 1 log higher in Atlox treated cells as compared to the controls. Monitoring the 51Cr release from Atlox treated cells indicated a temporary change in membrane structure of the cells as one of the mechanisms of virus enhancement.
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Authors | A A Qureshi |
Journal | Microbios
(Microbios)
Vol. 44
Issue 178
Pg. 107-15
( 1985)
ISSN: 0026-2633 [Print] England |
PMID | 3831715
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Chromium Radioisotopes
- Excipients
- Polyethylene Glycols
- atlox
- Fenitrothion
|
Topics |
- Cell Line
- Chromium Radioisotopes
- Conjunctiva
- DNA Replication
(drug effects)
- Excipients
(pharmacology)
- Fenitrothion
(pharmacology)
- Humans
- Influenza A virus
(genetics)
- Polyethylene Glycols
(pharmacology)
- Virus Replication
(drug effects)
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