Complement-induced thrombus formation on the surface of poly(N-vinylpyrrolidone)-grafted polyethylene.

Abstract

The role of complement activation in thrombogenesis was investigated on the surface of hydrophilic monomer-graft copolymerized polyethylene (PE) tubes. N-vinylpyrrolidone (NVP)-grafted tubes activated in an in vitro complement system of canine serum; but no activation occurred in 2-hydroxyethyl methacrylate (HEMA)-grafted tubes. The relative patent time for NVP-grafted tubes implanted in canine peripheral veins was shorter than that for HEMA-grafted tubes and adhesion of numerous leucocytes was observed on the luminal surfaces of the NVP-grafted tubes. Decomplementation by prior administration of cobra venom factor elongated the relative patent time for NVP-grafted tubes only and also inhibited the adhesion of leucocytes onto them. These results suggest that the complement activation participates in thrombus formation on the polymer surfaces in canine veins.

• Authors: H Fukumura, K Hayashi, S Yoshikawa, M Miya, N Yamamoto, I Yamashita
• Journal: Biomaterials (Biomaterials) Vol. 8 Issue 1 Pg. 74-6 (Jan 1987) ISSN: 0142-9612 [Print] Netherlands
• PMID: 3828451 (Publication Type: Journal Article)

Chemical References

• Biocompatible Materials
• Immunoglobulin G
• Polyethylenes
• Complement System Proteins
• Povidone

Topics

• Animals
• Biocompatible Materials
• Cell Adhesion
• Complement System Proteins (physiology)
• Dogs
• Humans
• Immune Adherence Reaction
• Immunoglobulin G
• In Vitro Techniques
• Microscopy, Electron, Scanning
• Polyethylenes (toxicity)
• Povidone (toxicity)
• Prostheses and Implants
• Surface Properties
• Thrombosis (physiopathology)