HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Contribution of hepatic fatty acid oxidation and exogenous galactose supply to the regulation of glucose homeostasis in the newborn rabbit.

Abstract
The inhibition of hepatic gluconeogenesis by 3-mercaptopicolinic acid (3-MPA) leads to a profound hypoglycemia in both suckling and fasting 24-hour-old rabbits. This hypoglycemia is totally reversed 1 h after the intragastric injection of an amount of galactose corresponding to the one ingested daily by the suckling newborns. This results from an active gluconeogenesis from galactose, which bypasses the site of inhibition by 3-MPA. However, this amount of galactose is not sufficient to maintain a normal blood glucose concentration for a long time, since 3 h after galactose injection, the blood glucose concentrations of newborn rabbits return to hypoglycemic values. When hepatic fatty acid oxidation is inhibited by 2-[6-(4-chlorophenoxy)hexyl]oxirane-2-carboxylate (POCA), 24-hour-old fasting rabbits become rapidly hypoglycemic secondary to a decrease in liver gluconeogenesis. The rate of hepatic gluconeogenesis is totally restored by giving medium-chain triglycerides, and the 24-hour-old rabbits become normoglycemic.
AuthorsJ P Pégorier, P H Duée, J R Girard
JournalBiology of the neonate (Biol Neonate) Vol. 51 Issue 1 Pg. 31-9 ( 1987) ISSN: 0006-3126 [Print] Switzerland
PMID3828415 (Publication Type: Journal Article)
Chemical References
  • Blood Glucose
  • Epoxy Compounds
  • Fatty Acids
  • Glucosephosphates
  • Ketone Bodies
  • Picolinic Acids
  • 2-(6-(4-chlorophenoxy)hexyl)oxirane-2-carboxylic acid
  • Glucose-6-Phosphate
  • 3-mercaptopicolinic acid
  • Phosphoenolpyruvate Carboxykinase (GTP)
  • Galactose
Topics
  • Animals
  • Animals, Newborn (metabolism)
  • Blood Glucose (metabolism)
  • Epoxy Compounds (pharmacology)
  • Fatty Acids (metabolism)
  • Galactose (metabolism)
  • Gluconeogenesis (drug effects)
  • Glucose-6-Phosphate
  • Glucosephosphates (metabolism)
  • Homeostasis
  • Ketone Bodies (metabolism)
  • Liver (drug effects, metabolism)
  • Oxidation-Reduction (drug effects)
  • Phosphoenolpyruvate Carboxykinase (GTP) (antagonists & inhibitors)
  • Picolinic Acids (pharmacology)
  • Rabbits

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: